Impact of embryo culture and day of embryo transfer on the cardiometabolic health of adult mice†.

ABSTRACT: Assisted reproductive technologies (ARTs) have rapidly evolved since being introduced in 1978. However, many of the procedures used clinically lack a basis of long-term studies to ensure their safety. Though in vitro fertilization (IVF) is largely safe, follow-up studies have shown that IVF-conceived children may show signs of altered fat deposition, increased fasting glucose, and increased blood pressure. These results are, however, limited by a low number of patients and different ART variables (different lengths of embryo culture or different types of culture media). Results of studies using animal models have confirmed many of these results and shown that more stressful culture conditions result in disrupted adult phenotypes. Presently, it is unclear if culture conditions such as durat

SUBMITTER: Simbulan RK 

PROVIDER: S-EPMC12448587 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature