Genetic Variants Associated With the Biochemical Response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Context

The response to treatment with vitamin D varies between patients.

Objective

To identify genetic variants associated with the biochemical response to vitamin D3 supplementation.

Design

Randomized placebo-controlled trial conducted between 2017 and 2019.

Setting

The trial was nested in an ongoing community-based cohort study, the Multi-Ethnic Study of Atherosclerosis.

Intervention

2000 International Units of vitamin D3 or placebo daily for 16 weeks.

Participants

The analytic sample included 427 participants assigned to vitamin D3 (mean age, 73 years; 54% females) and was 36% White, 33% Black, 18% Hispanic, and 14% Chinese.

Main outcome measures

The biochemical response to vitamin D3 included changes in serum concentrations of 1,25-dih

SUBMITTER: Best CM 

PROVIDER: S-EPMC12448636 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature