HIV-1 Viremia and Cancer Risk in 2.8 Million People: The South African HIV Cancer Match Study.

ABSTRACT:

Background

Most research on human immunodeficiency virus-1 (HIV-1) viremia and cancer risk is from high-income countries. We evaluated the association between HIV-1 viremia and the risk of various cancer types among people with HIV (PWH) in South Africa.

Methods

We analyzed data from the South African HIV Cancer Match study, based on laboratory measurements from the National Health Laboratory Service and cancer records from the National Cancer Registry from 2004 to 2014. Using Cox proportional hazards models, we estimated hazard ratios (HR) for cancer incidence per unit increase in time-updated Log10 HIV-1 RNA viral load copies/mL. We created partially adjusted (sex, age, calendar year) and fully adjusted models (additionally including time-updated CD4 count).

Results

SUBMITTER: Ruffieux Y 

PROVIDER: S-EPMC12448642 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature