The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents.

ABSTRACT: A large body of research suggests that stress can affect how the immune system responds to vaccines. The impact of mental health disorders on humoral antibody response following immunization is not well understood, particularly for the COVID-19 vaccines. Leveraging a population-based longitudinal cohort assessing SARS-CoV-2 incidence in central North Carolina, we sought to investigate the relationship between mental health and immune response to vaccination. The 106 participants responded to biweekly surveys and contributed monthly serum samples that underwent SARS-CoV-2 spike antibody testing via enzyme-linked immunosorbent assay (ELISA). Utilizing weighted generalized linear models, we measured the association between depressive symptoms as recorded on the CESD-20 and quantitative antibo

SUBMITTER: Cassidy CA 

PROVIDER: S-EPMC12448651 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature