Prognostic implication of <i>CDKN2A/B</i> homozygous deletion on histological grades in isocitrate dehydrogenase-mutant astrocytomas: A systematic review and meta-analysis.

ABSTRACT:

Background

Isocitrate dehydrogenase-mutant astrocytomas (A-IDHm) with the homozygous deletion of cyclin-dependent kinase 2A/B (CDKN2A/B-HD) have been classified as grade 4 in the WHO 2021 classification (WHO2021). This study aimed to find survival differences in subgroups stratified by CDKN2A/B status and traditional histological grades (hGs).

Methods

The frequency and prognostication of CDKN2A/B-HD in primary A-IDHm were analyzed based on hGs. A systematic review and meta-analysis were performed following the PRISMA guidelines using three databases (registration CRD42024570409). Effect sizes were evaluated using the hazard ratio (HR) and restricted mean survival time (RMST) for overall survival (OS).

Results

Thirty-three articles with 3739

SUBMITTER: Nakasu S 

PROVIDER: S-EPMC12448685 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature