Profiling the immune tumor microenvironment of pediatric brain tumors with cavitron ultrasonic surgical aspirator (CUSA)-derived tissue fragments.

ABSTRACT:

Background

Current treatment options for pediatric high-grade brain tumors are limited, with poor 5-year overall survival rates. While immunotherapy is promising for these patients, the composition of their tumor immune microenvironment (TIME) is still not fully understood, due to the limited availability of tumor material for research. Given the high abundance of tumor tissue fragments obtained using the cavitron ultrasonic surgical aspirator (CUSA), these samples could serve as a resource for research and diagnostic purposes.

Methods

To evaluate CUSA tissue fragments as an alternative source for immune-landscape evaluation of brain tumors, we conducted immunological profiling on matched biopsy and CUSA-derived tissue fragments taken during resection from 11 pediatric brain

SUBMITTER: Meesters-Ensing JI 

PROVIDER: S-EPMC12448718 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature