Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.

ABSTRACT: Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we recorded intracranial EEG data from a cohort of patients with medically refractory epilepsy as they completed a visual recognition memory task. During the memory task, brief trains of intracranial theta burst stimulation (TBS) were delivered to the basolateral amygdala (BLA). Using simultaneous microelectrode recordings, we isolated neurons in the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex and tested whether stimulation enhanced or suppressed firing rates. Additionally, we characterized the properties of modulated neurons,

SUBMITTER: Campbell JM 

PROVIDER: S-EPMC12448748 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature