The INSPIRE-T longitudinal observational study centered on intrinsic capacity: baseline data.

ABSTRACT:

Background

The "INStitute for Prevention," "healthy agIng," and "medicine REjuvenative" "Translational" (INSPIRE-T) study is a 10-year observational study. The primary objective of which is to study trajectories of aging across lifespan from the perspective of intrinsic capacity (IC) through deep clinical and biological phenotyping.

Methods

IC was assessed in the INSPIRE-T cohort stratified by age (10-year age groups) using the World Health Organization (WHO) integrated care for older people (ICOPE) program. Biospecimens (biofluids, dental plaque, nasopharyngeal swabs, stools, hair follicles, and skin biopsies) were also collected for biomarker studies and drug-target identification for the prediction and prevention of IC declines respectively.

Results

The INSPIRE-T b

SUBMITTER: Guyonnet S 

PROVIDER: S-EPMC12448789 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature