Salvage therapies for first relapse of SHH medulloblastoma in early childhood.

ABSTRACT:

Background

Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood medulloblastoma (iMB) and has no standard of care at relapse. This work aimed to evaluate the post-relapse survival (PRS) and explore prognostic factors of patients with nodular desmoplastic (ND) and/or SHH iMB.

Methods

This international retrospective study included 147 subjects diagnosed with relapsed ND/SHH iMB between 1995 and 2017, <6 years old at original diagnosis, and treated without initial craniospinal irradiation (CSI). Univariable and multivariable Cox models with propensity score analyses were used to assess PRS for those in the curative intent cohort.

Results

The 3-year PRS was 61.6% (95% confidence interval [CI], 52.2-69.6). The median age at

SUBMITTER: Erker C 

PROVIDER: S-EPMC12448823 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature