Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase.

ABSTRACT: Methionine restriction (MR) has many effects on different molecular and physiological systems and pathways associated with aging. However, these outcomes have often been ambiguous across studies, suggesting the context of outcomes, including tissue type or donor sex, may have a significant impact. We have previously shown that methionine sulfoxide reductase A (MsrA) may have discrete roles on aging physiology under MR. Here, we investigated the effect of MR on putative molecular hallmarks of aging, including mitochondrial function and regulation of the intracellular signal hydrogen sulfide, across tissues and in males and females. We found that females tended to have greater changes in mitochondrial oxygen consumption than males with MR, while the effects of MsrA were context-dependent. Mi

SUBMITTER: Thyne KM 

PROVIDER: S-EPMC12448830 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature