A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry.

ABSTRACT:

Background

Improving the surgical outcomes for commonly occurring spinal neoplasms of extradural and intradural extramedullary origins requires precise intraoperative diagnosis provided by highly trained neuropathologists.

Methods

Through a retrospective study of n = 319 patient specimens, verified where appropriate by learning curve analysis to be sufficient for statistically significant observations, we aimed to assess the utility of 10-second picosecond infrared laser mass spectrometry (MS; PIRL-MS) for non-subjective diagnosis of major spinal tumor types of metastatic carcinoma, schwannoma, and meningiomas.

Results

The sensitivity and specificity values of spinal tumor-type diagnosis (based on n = 182 independent specimens) were (93% ± 1)% and (97% ± 2)%, respecti

SUBMITTER: Fiorante A 

PROVIDER: S-EPMC12448866 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature