PMMA bone cement with AgNP@CDs nanocomposite for infection control and inflammation mitigation.

ABSTRACT: Bioinert poly(methyl methacrylate) (PMMA) is widely employed as a bone cement material in orthopedic and trauma surgery applications; however, its susceptibility to bacterial infection and bioinert nature limits its clinical applications. In this study, we developed a PMMA-based bone cement incorporating a silver nanoparticle-carbon dots (AgNP@CDs) nanocomposite (∼70 nm) at concentrations (2 wt%) with a Young's modulus (324.74 ± 7.08 MPa) to simultaneously combat bacterial infections, minimize cytotoxicity and support tissue regeneration. The CDs stabilize and functionalize AgNPs, improving their dispersion and bioavailability while enabling the controlled and sustained release of antimicrobial ions through incorporation with bone cement. The antibacterial efficacy of the composite was tho

SUBMITTER: Ullah I 

PROVIDER: S-EPMC12448944 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature