Anti-Nonstructural Protein 1 Antibody Kinetics and Their Association With Disease Severity in Pediatric Dengue.

ABSTRACT:

Background

Dengue is an immune-mediated disease with severe manifestations often linked to secondary infections. Dengue virus nonstructural protein 1 (DENV NS1) and corresponding antibodies are thought to play a crucial role in disease pathogenesis.

Methods

This study investigated the kinetics of anti-NS1 antibody responses in relation to NS1 levels and NS1 immune complexes (ICs) in pediatric dengue patients with varying disease severity following secondary DENV infections with all four serotypes, using retrospective plasma samples collected in Thailand and analyzed by enzyme-linked immunosorbent assays (ELISAs). Plasma samples from pediatric patients with other febrile illnesses (OFI) and healthy adults served as non-dengue control groups.

Results

Anti-NS1 IgG (parti

SUBMITTER: Noisakran S 

PROVIDER: S-EPMC12448948 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature