Participant Perspectives in an HIV Treatment Interruption Study in San Francisco, United States.

ABSTRACT: HIV cure-related clinical research studies often include analytical treatment interruptions (ATIs), in which participants pause antiretroviral treatment (ART). During ATIs, researchers closely monitor laboratory values and adverse events. We assessed and compared the perspectives of two distinct groups of participants: HIV noncontrollers and controllers in a San Francisco-based ATI study focused on identifying biomarkers predicting HIV viral rebound. Data were collected from 2021 to 2024 over five study time points to assess motivations, understanding of the study, decisional regret, and partner protections. All participants (n = 16) endorsed the goal of helping advance HIV research as a motivator, about half were also driven by interest in their body's response to the ATI, and some indica

SUBMITTER: Nguyen E 

PROVIDER: S-EPMC12448951 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature