Infectious Complications Following CD30 Chimeric Antigen Receptor T-cell Therapy in Adults.

ABSTRACT: Infections are increasingly recognized as a complication of chimeric antigen receptor T-cell (CAR-T) therapy however the incidence of infections after non-CD19 targeted CAR-T is not yet known. We report, for the first time, infectious complications after CD30 CAR T-cell treatment for patients with Hodgkin lymphoma and peripheral T-cell lymphoma. We retrospectively evaluated all 64 adult patients with relapsed/refractory CD30+ lymphomas who received anti-CD30 CAR T-cells at a single institution between 2016-2021. We assessed microbiologically confirmed infections within 1 year after cell infusion, censoring for relapse. We calculated infection density (total infections per 100 patient-days-at-risk), and cumulative incidence of infection divided into time periods postinfusion (days 0-28, 29-

SUBMITTER: Cao F 

PROVIDER: S-EPMC12449069 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature