Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy.

ABSTRACT:

Background

One in ten Americans carry a lifetime risk of ischemic heart failure, the most severe form of ischemic heart disease. Carrying a nearly 50% five‑year mortality rate, no interventional therapy exists to treat the underlying cause, microvascular malperfusion. In efforts to combat microvascular malperfusion, our group has utilized synergistic application of endothelial progenitor cells (EPCs) and smooth muscle cells (SMCs) to induce angiogenesis in ischemic myocardium.

Methods

Cells are then embedded into a rapidly manufacturable compressed collagen (CC) patch to provide a biosimilar scaffold ready for transplantation. The performance of the cellular compressed collagen patch was then tested on a rodent acute myocardial infarction model of ischemic heart failure.

SUBMITTER: Pfrender E 

PROVIDER: S-EPMC12449208 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature