Role of Trimethylamine N-Oxide in Assessing Plaque Instability of the Culprit Lesion in Chinese Patients With ST-Elevation Myocardial Infarction: Insights From a 7-Year Long-Term Follow-Up Study.

ABSTRACT: This study investigated the relationship between trimethylamine N-oxide (TMAO) levels and plaque instability in Chinese patients with ST-elevation myocardial infarction (STEMI) using optical coherence tomography (OCT), with a 7 -year follow-up. Between January 1, 2017, and December 31, 2018, 188 Chinese patients with STEMI who underwent OCT at the Second Affiliated Hospital of Harbin Medical University were enrolled. Patients were stratified into low TMAO (≤ 2.54 μM) and high TMAO (> 2.54 μM) groups. The primary endpoint was major adverse cardiovascular events (MACE: all-cause mortality, reinfarction, target vessel revascularization, and stroke). Compared with the low TMAO group, the high TMAO group showed a higher incidence of plaque rupture and a lower incidence of plaque erosion. Labora

SUBMITTER: Xiu L 

PROVIDER: S-EPMC12449236 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature