ScPOEM: robust co-embedding of peaks and genes revealing peak-gene regulation.

ABSTRACT:

Motivation

Identifying regulatory elements in various chromosomal regions that influence gene expression is a fundamental challenge in epigenomics, with profound implications for understanding gene regulation and disease mechanisms. The advent of paired single-cell RNA sequencing and single-cell ATAC sequencing has created unprecedented opportunities to address this challenge by enabling simultaneous profiling of gene expression and chromatin accessibility at single-cell resolution. However, the inherent signals between them are weak due to the highly sparse and noisy nature of data.

Results

This article proposes single-cell meta-Path based Omics Embedding (scPOEM), a novel embedding method that jointly projects chromatin accessibility peaks and expressed genes into a shared

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12449255 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature