Pretreatment intravoxel incoherent motion histogram metrics and clinical characteristics for prediction of perineural invasion status and survival in patients with rectal cancer.

ABSTRACT:

Objectives

To explore intravoxel incoherent motion (IVIM) for evaluation of the perineural invasion (PNI) status and survival in patients with rectal cancer.

Materials and methods

The true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and microvascular volume fraction (f) were recorded together with histogram metrics. Differences in IVIM histogram metrics between the PNI-positive group and the PNI-negative group were analyzed. Univariable and multivariable logistic regression analysis were used for model construction. The area under the receiver operating characteristic curve (AUC) was used to assess the diagnostic performance of the models. Histopathology was used as the PNI endpoint. Kaplan-Meier curve analysis was employed to estimate the disease-free surv

SUBMITTER: Yang A 

PROVIDER: S-EPMC12449288 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature