Low expression of HSP27 and HSP70 predicts poor prognosis in laryngeal squamous cell carcinoma.

ABSTRACT:

Purpose

Molecular alterations drive the pathogenesis of laryngeal squamous cell carcinoma (LSCC), yet reliable prognostic biomarkers remain elusive. Heat shock proteins (HSPs), which mediate cellular stress responses, are implicated in cancer progression and treatment resistance. This study aimed to evaluate whether HSP27 and HSP70 expression correlate with clinicopathological features and survival outcomes in LSCC. Specifically, we assessed their potential as prognostic biomarkers in this malignancy.

Methods

Immunohistochemistry was performed on 158 LSCC tissue samples from 40 patients and compared to 30 normal laryngeal tissue samples. Expression levels of HSP27 and HSP70 were correlated with clinicopathological variables. Validation was conducted using transcriptomic and

SUBMITTER: Borowczak J 

PROVIDER: S-EPMC12449290 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature