Modular breast and tumor perfusion phantoms for 4D dynamic contrast-enhanced dedicated breast CT.

ABSTRACT:

Background

Tumor heterogeneity presents significant challenges in breast cancer diagnosis and treatment. Four-dimensional dynamic contrast-enhanced dedicated breast CT (4D DCE-bCT) is a novel imaging technique designed to capture contrast agent kinetics with high spatial and temporal resolution, enabling detailed assessment of tumor perfusion and heterogeneity.

Purpose

To develop modular breast tumor phantoms capable of simulating a range of physiologically relevant perfusion patterns and structural heterogeneities for validation of 4D DCE-bCT.

Methods

Tumor phantoms (1.5 cm diameter) were 3D-printed using clear resin in several designs: small-channel phantoms (0.8 and 1.0 mm diameter), a leaking vessel model with permeable outer walls, gyroid structures (1.3 and 1.5 

SUBMITTER: Goris LC 

PROVIDER: S-EPMC12449291 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature