Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.

ABSTRACT:

Background

Maternal health during pregnancy appears to impact childhood cancer risk, yet comprehensive studies remain scarce. This study investigates associations between childhood cancer and multiple maternal comorbidities.

Methods

A population-based case-control study was conducted using Danish national registers, with maternal health conditions identified from the National Patient Register and Medical Births Registry. We employed the Obstetric Comorbidity Index using ICD-8 and ICD-10 codes. The study population (1977-2013) included 6419 cases and 160484 matched controls. Conditional logistic regression estimated pediatric cancer risk.

Results

A maternal comorbidity score of one or more was linked to acute lymphocytic leukemia (ALL; OR = 1.07, 95%CI: 1.03-1.12), ret

SUBMITTER: Yin C 

PROVIDER: S-EPMC12449446 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature