Association between low-dose aspirin use and breast cancer recurrence: a Danish nationwide cohort study with up to 23 years of follow-up.

ABSTRACT:

Background

The anti-cancer potential of low-dose aspirin in long-term breast cancer (BC) survivors remain unknown. We evaluated the association between low-dose aspirin use and BC recurrence and mortality.

Methods

Women ≥40 years diagnosed with stage I-III BC (1996-2004) were identified from the Danish Breast Cancer Group (DBCG) database and information on aspirin use from the Danish Prescription Registry. We ascertained recurrences from DBCG and via a validated algorithm. We plotted cumulative incidences of recurrence and mortality, accounting for competing risks. Using Cox regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CI), employing landmark analyses at 5-, 10-, and 15-year post-diagnosis.

Results

Among 20,509 BC survivors, 4527 develope

SUBMITTER: Solmunde E 

PROVIDER: S-EPMC12449462 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature