Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population.

ABSTRACT:

Background

BOADICEA is a widely used algorithm for predicting breast and ovarian cancer risks, using a combination of genetic and lifestyle, hormonal and reproductive risk factors. However, it has largely been developed using data from White/European individuals, limiting its applicability to other ethnicities. Here, we updated BOADICEA to provide ethnicity-specific risk estimates.

Methods

We utilised data from multiple sources to derive estimates for the distributions and effect sizes of risk factors in major UK ethnic groups (White, Black, South Asian, East Asian, and Mixed), along with ethnicity-specific population cancer incidences. We also developed a method for deriving adjusted polygenic scores for individuals of mixed genetic ancestry.

Results

The predicted av

SUBMITTER: Ficorella L 

PROVIDER: S-EPMC12449465 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature