Linking genetics to MRI-DTI: <i>HFE</i> polymorphism delays Alzheimer's disease white matter degeneration in <i>APOE4</i> carriers.

ABSTRACT: BackgroundWhile APOE4 mutation impacts normal myelination through disruptions of iron and lipid homeostasis, the HFE (homeostatic iron regulatory gene) polymorphism directly participates in white matter (WM) myelination and neuroinflammations processes via modulating iron homeostasis.ObjectiveThis study investigated effects of HFE polymorphism in APOE4 gene carriers in the context of WM degeneration and neuroinflammation in Alzheimer's disease (AD).MethodsWM degeneration in AD subjects of APOE4 carriers with and without HFE H63D polymorphism was evaluated and compared with age- and sex-matched cognitive normal (CN) groups using diffusion tensor imaging (DTI) data from the Alzheimer's Disease Neuroimaging Initiative database.ResultsDTI radial and me

SUBMITTER: Pang R 

PROVIDER: S-EPMC12449602 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature