Transdiagnostic Effects of a Chinese Herbal Formula DEP-2306 on Improving Sleep and Mood in Adults With Depressive Episode With Insufficient Symptoms: A Real-World Study.

ABSTRACT: This study aimed to characterize the changes in sleep and mood and assess the safety of a Chinese herbal formula Depression (DEP)-2306 in adults with a depressive episode with insufficient symptoms (DEIS). Additionally, it explored the factors associated with the outcome remission with significant improvement. Between June 2023 and January 2024, 67 DEIS patients were administered daily DEP-2306 over 4 weeks. The main outcomes included depression severity (Patient Health Questionnaire-9 [PHQ-9] and Hamilton depression rating scale [HAMD-17]), anxiety severity (General Anxiety Disorder-7 [GAD-7]), and sleep quality (Pittsburgh Sleep Quality Index [PSQI]). A linear mixed model was used to analyse the score changes, and logistic regression was used to identify factors associated with the outco

SUBMITTER: Tang HT 

PROVIDER: S-EPMC12449661 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature