Sulfiredoxin stimulates luteinization in vitro by promoting progesterone production in rats.

ABSTRACT:

In brief

Sulfiredoxin (Srxn1) is essential for corpus luteum formation during ovulation. Inhibition of Srxn1 with J14 suppressed LH-stimulated progesterone production, key gene expressions (Cyp11a1, StAR), and markers of luteinization. This highlights Srxn1's role in promoting LH-induced luteinization through the ERK, C/EBPβ, and Cyp11a1 pathways.

Abstract

Sulfiredoxin (Srxn1), an antioxidant enzyme, is expressed during ovulation. This study aimed to investigate the physiological function of Srxn1 in corpus luteum formation during the ovulatory process in rat. Treatment of cultured preovulatory follicles with the Srxn1 inhibitor, J14, suppressed LH-stimulated progesterone production, but not estradiol production, in a dose-dependent manner. Likewise, LH-stimulated gene expre

SUBMITTER: Chun SY 

PROVIDER: S-EPMC12449702 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature