METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.

ABSTRACT: Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis have not been fully elucidated. Recently, m6A RNA modification has been found to regulate various biological processes. This study aimed to investigate the status of ferroptosis in adenomyosis and explore how m6A modification regulates key genes associated with ferroptosis. The research revealed ferroptosis presented in both eutopic and ectopic endometrial tissues of individuals with adenomyosis. Additionally, a decrease in RNA m6A modification levels and a reduction in GPX4 protein expression were observed. GPX4 may serve as a biomarker reflecting the

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12449703 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature