Bioinspired nanoparticles prevent blue-light-induced skin hyperpigmentation via FZD2-TYR-melanin pathway.

ABSTRACT: Melanin is the natural physiological defense for skin, but excessive melanin production can result in conditions like hyperpigmentation and melasma. In addition to UV light, visible light, especially blue light, has been recognized as an extra factor contributing to cutaneous hyperpigmentation and premature photoaging. However, there are currently no effective protective agents against blue light. Within this research, we obtained polydopamine nanoparticles (PDA NPs) and cuttlefish ink nanoparticles (CINPs), which are inspired by endogenous melanin. Our research confirmed that PDA NPs and CINPs shared similar structural and functional properties with natural melanin. Otherwise, these nanoparticles not only exhibited excellent photostability and broad-spectrum ultraviolet-visible light abso

SUBMITTER: Chen X 

PROVIDER: S-EPMC12449806 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature