Association of Lipid Profile With Cardiovascular Diseases and All-Cause Death: A 2-Decade Follow-Up of the Tehran Lipid and Glucose Study.

ABSTRACT:

Background

We investigated the associations between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and triglycerides with all-cause and cardiovascular disease death among participants in the TLGS (Tehran Lipid and Glucose Study) cohort.

Methods

We included 8241 participants aged ≥30 years, who were followed until 2018. Lipid profiles were assessed as both continuous and categorical variables (quintiles) using the restricted cubic spline and Cox proportional hazards model.

Results

During a median follow-up of 18.1 years, 1002 and 369 individuals died from all causes and cardiovascular disease, respectively. A U-shaped association was found between non-HDL-C and the risk of all-cause death. In the categor

SUBMITTER: Ramezankhani A 

PROVIDER: S-EPMC12449900 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature