Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes.

ABSTRACT:

Background

Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR.

Methods

A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 years) with degenerative MR prospectively quantified and graded mild or moderate. Primary end point was survival under medical management. Secondary outcome was survival throughout follow-up stratified by performance of early mitral surgery within 3 months postdiagnosis.

Results

Amo

SUBMITTER: Topilsky Y 

PROVIDER: S-EPMC12449906 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature