Prevalence and Prognostic Value of the Novel Consensus Definition of Metabolic Hyperferritinemia in Patients With Heart Failure With Preserved Ejection Fraction Across Different Glucose Metabolism States.

ABSTRACT:

Background

Metabolic hyperferritinemia (MHF) is associated with the occurrence and progression of cardiovascular disease. Our aim is to investigate the prevalence of MHF, as defined by the latest consensus, and validate its association with major adverse cardiovascular events (MACEs) in heart failure with preserved ejection fraction with different glucose metabolism conditions.

Methods and results

This retrospective study included 7498 patients with heart failure with preserved ejection fraction, with a median follow-up duration of 2.5 years. MHF is defined as an elevation in serum ferritin accompanied by metabolic dysfunction, and is categorized into different grades based on ferritin levels. The outcome of the study is MACEs. Among the 7498 patients with heart failure with

SUBMITTER: Ni W 

PROVIDER: S-EPMC12449925 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature