Sleep Duration Irregularity and Risk for Incident Cardiovascular Disease in the UK Biobank.

ABSTRACT:

Background

Emerging evidence supports a link between circadian disruption as measured by higher night-to-night variation in sleep duration and increased risk of cardiovascular disease (CVD). It remains unclear whether this association varies by CVD types or may be modified by average sleep duration and genetic risk for CVD.

Methods

Our prospective analysis included 86 219 UK Biobank participants who were free from CVD when completing 7 days of accelerometer measurement from 2013 to 2015. Sleep irregularity was evaluated by the SD of accelerometer-measured sleep duration over 7 days. Incident major CVD events, defined as fatal or nonfatal myocardial infarction and stroke, were identified through linkage to Hospital Episode Statistics data until May 31, 2022. Multivariable-adj

SUBMITTER: Huang T 

PROVIDER: S-EPMC12449928 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature