Left Atrial Stiffness Is Increased in Pediatric Hypertrophic Cardiomyopathy and Offers Incremental Value in Predicting Major Adverse Cardiac Events in This Group.

ABSTRACT:

Background

Determining risk factors by echocardiography to prevent major adverse cardiac events (MACE) is crucial in pediatric patients with hypertrophic cardiomyopathy. Recent studies have shown that left atrial (LA) stiffness may serve as surrogate marker in children, to differentiate elevated pulmonary capillary wedge pressure from normal.

Methods

We retrospectively enrolled 239 pediatric patients with hypertrophic cardiomyopathy. They were divided into 2 groups: MACE (n=79) and non-MACE (n=160) groups. Noninvasive LA stiffness was calculated as the ratio of average E/e' to peak LA strain obtained by 2-dimensional speckle-tracking echocardiography. Baseline evaluation was defined as the echocardiogram performed at the time of referral, before the occurrence of a MACE, inc

SUBMITTER: Numata R 

PROVIDER: S-EPMC12449951 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature