Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) could affect blood pressure regulation by suppressing gastric acid required for the conversion of oral nitrite into nitric oxide. Whether PPI use is associated with incident hypertension remains unknown.

Methods

We included 64 720 menopausal women who were free from cardiovascular disease and hypertension at enrollment in the Women's Health Initiative Observational Study (1993-1998). Baseline PPI use and duration were determined using medication inventories. The outcome was physician diagnosed/treated incident hypertension, assessed by self-report on annual questionnaires. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazard models for incident hypertension according to baseline PPI use (no/yes) a

SUBMITTER: Soliman AI 

PROVIDER: S-EPMC12449964 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature