Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study.

ABSTRACT:

Background

Excess epicardial adipose tissue (EAT) has been associated with cardiovascular diseases such as atrial fibrillation, coronary artery disease, and heart failure. The metabolomic signature of EAT is not well studied.

Methods

Untargeted 1H nuclear magnetic resonance metabolomics profiling of serum was performed (1-dimensional nuclear magnetic resonance, Carr-Purcell-Meiboom-Gill Echo Train Acquisition, lipidomics) and EAT was measured with computed tomography in MESA (Multi-Ethnic Study of Atherosclerosis; N=3936) and the Rotterdam study (N=465). Associations between fasting serum metabolites and EAT volume were assessed using cross-sectional linear regression of individual-level data in MESA and validated in Rotterdam.

Results

A total of 23 571 metabolomic sp

SUBMITTER: Neeland IJ 

PROVIDER: S-EPMC12449973 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature