Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation.

ABSTRACT:

Background

Infective endocarditis (IE) can be complicated by acute heart failure and bacteremia, which can account for increased mortality. The role of anticoagulation with warfarin in IE is controversial. This study aimed to study the effects of anticoagulation with warfarin on survival in patients with IE, through reducing the risks of thromboembolism and possibly shortening infection time.

Methods

This was a retrospective population-based cohort study using the Clinical Data Analysis and Reporting System from Hong Kong. Patients diagnosed with IE between January 1, 1997 and August 31, 2020 were identified using International Classification of Diseases, Ninth Revision (ICD-9) codes. A target pragmatic trial was emulated using the observational data with cloni

SUBMITTER: Lee TTL 

PROVIDER: S-EPMC12449976 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature