Incremental Prognostic Value of Hippocampal Metabolic Activity for Sudden Cardiac Death in Patients With Heart Failure With Reduced Ejection Fraction.

ABSTRACT:

Background

Hippocampal injury is linked to cognitive impairment and cardiac events in patients with heart failure with reduced ejection fraction. However, the predictive value of hippocampal metabolic activity (HMA) for sudden cardiac death (SCD) and the underlying mechanisms remain unclear. This study aimed to evaluate the independent and incremental predictive value of HMA over myocardial scar for SCD-related events in patients with heart failure with reduced ejection fraction and to explore the potential mechanism.

Methods

This prospective study included 270 patients with heart failure with reduced ejection fraction undergoing gated single-photon emission computed tomography and brain/cardiac ¹⁸F-fluorodeoxyglucose positron emission tomography. HMA and myocardi

SUBMITTER: Shi Z 

PROVIDER: S-EPMC12449996 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature