Femoral Vessel Occlusion Enhances Cardiac and Cerebral Perfusion in a Porcine Model of Cardiac Arrest.

ABSTRACT:

Background

Closed chest compressions during cardiopulmonary resuscitation (CPR) mechanically circulate blood to the organs during cardiac arrest, yet cardiac arrest remains among the most fatal diseases, with a mortality rate that exceeds 85% to 90% globally. Novel methodologies to improve organ perfusion, particularly in resource-restricted settings, are overdue. This study evaluated the efficacy of external femoral vessel occlusion (FVO) during CPR in a large mammal model.

Methods

Thirteen adult Yorkshire pigs were instrumented with vascular and electrophysiologic monitoring lines. Hemodynamic measures and cardiac and cerebral perfusion in the pre- and postarrest conditions were quantified via fluorescent microspheres infused into the circulation. Control (n=7) animals und

SUBMITTER: Kim JY 

PROVIDER: S-EPMC12450009 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature