All-optical mapping reveals distributed suppression of cortical sensory responses after optogenetic silencing.

ABSTRACT:

Significance

We designed a novel all-optical tool to simultaneously silence neuronal activity at arbitrary sites on the dorsal cortex, and monitor the consequences of the manipulation. Optogenetic inhibition of primary sensory regions determined short and long-term dampening of the sensory response across a distributed cortical network.

Introduction

Many fundamental processes of brain computation, such as sensory perception and motor control, heavily rely on the mesoscopic dynamics of activity across the cerebral cortex. Manipulating mesoscale activity and observing its effects across multiple brain regions is crucial for understanding the causal link between cortical dynamics and behavior.

Objective

The goal of this study was to develop a novel all-optical system tha

SUBMITTER: Ambrosone M 

PROVIDER: S-EPMC12450112 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature