Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.

ABSTRACT:

Background

Traffic pollution exposure has been associated with adverse cardiovascular outcomes, but determinants of individual susceptibility remain unclear. To explore whether disease status modifies traffic-related cardiac responses and to examine the cardioprotective role of nitro linoleic acids.

Methods

In a crossover study, 39 chronic obstructive pulmonary disease (COPD) patients, 38 ischemic heart disease (IHD) patients, and 39 healthy participants walked for two hours on traffic-congested Oxford Street and in traffic-free Hyde Park, in random order, on separate days. Cardiac electrical activity, including heart rate, heart rate variability (HRV), QT interval, and ST-segment changes, was continuously monitored for 24 h. At 24 h following the walk, a urine void was coll

SUBMITTER: Meng X 

PROVIDER: S-EPMC12450113 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature