Sanguineous cardiopulmonary bypass prime accelerates the inflammatory response during pediatric cardiac surgery.

ABSTRACT:

Background

The inflammatory response to cardiopulmonary bypass (CPB) in pediatric patients remains an unresolved challenge. Sanguineous CPB prime, composed of allogenic blood products, is one potentially important stimulus. This study aims to identify specific inflammatory mediators active in sanguineous CPB prime and their impact on the inflammatory response at CPB initiation.

Methods

In a post-hoc analysis of a prospective observational cohort study (NCT05154864), where pediatric patients undergoing cardiac surgery with CPB were enrolled after informed consent, patients were grouped by CPB prime type (sanguineous vs crystalloid). Arterial samples were collected post-sternotomy as a baseline and again at CPB initiation from all patients. In the sanguineous<

SUBMITTER: Bierer J 

PROVIDER: S-EPMC12450242 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature