Efficacy of intraoperative ketamine/esketamine in the prevention of postoperative delirium: a systematic review and meta-analysis.

ABSTRACT:

Background

Postoperative delirium (POD) is associated with higher risks of postoperative complications ‌and‌ mortality (2- to 3-fold increase). Studies investigating the effect of intraoperative ketamine on POD risk have yielded conflicting results. This study aimed to assess the effects of intraoperative ketamine and its more potent version, esketamine, on POD.

Design

Systematic review and meta-analysis.

Objective

To evaluate the effect of intraoperative ketamine/esketamine on the incidence of POD.

Methods

We adhered to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and searched the PubMed, Embase, Medline (Ovid), Cochrane, Scopus, and Web of Science databases for the MeSH terms "ketamine" and "emergence delirium" from

SUBMITTER: Chen C 

PROVIDER: S-EPMC12450268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature