Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model.

ABSTRACT: Copper oxide nanoparticles (CuONPs) are increasingly used across various industrial applications, raising concerns about their potential toxicity and necessitating comprehensive safety evaluations. In this study, we first evaluated the respiratory toxicity of CuONP exposure in a mouse model of asthma. CuONP exposure alone exacerbated asthma symptoms, as evidenced by increased airway hyperresponsiveness, inflammatory cell infiltration, and elevated cytokine production with increasing thioredoxin-interacting protein (TXNIP) expression. We then investigated whether TXNIP functions as a critical regulator of asthma exacerbation by examining the effects of TXNIP on the same experimental models using induced TXNIP-overexpressed mice induced by intratracheal injection of adeno-associated virus (A

SUBMITTER: Kim WI 

PROVIDER: S-EPMC12450567 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature