Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy.

ABSTRACT:

Aims

Emerging evidence suggests sex-specific differences in platelet biology and clinical responses to antiplatelet agents. Light transmission aggregometry (LTA) represents the historical gold standard for the assessment of platelet reactivity but is influenced by pre-analytical and analytical variables. We analysed a large dataset of patients undergoing LTA using a standardized methodology to investigate the impact of sex on platelet reactivity with or without antiplatelet therapy.

Methods and results

Between 2004 and 2022, 11,913 patients sequentially underwent LTA assessments following stimulation with adenosine diphosphate (ADP) (2 µM), collagen (2 µg/mL), arachidonic acid (AA, 0.5 mM), and epinephrine (10 µM). After applying study entry criteria, 5687 patients were incl

SUBMITTER: Galli M 

PROVIDER: S-EPMC12450592 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature