Comparative effectiveness and safety of dual antiplatelet therapy with ticagrelor vs. clopidogrel in older adults with acute coronary syndrome: a target trial emulation study.

ABSTRACT:

Aims

There is conflicting trial evidence on the comparative effects of dual antiplatelet therapy (DAPT) with ticagrelor vs. clopidogrel in older patients with acute coronary syndromes (ACS). We aimed to assess the risk of major adverse cardiovascular events (MACE) and major bleeding in ACS patients ≥75 years initiating ticagrelor vs. clopidogrel treatment.

Methods and results

We used healthcare data from the Stockholm region (2011-2021) to emulate a hypothetical target trial comparing ticagrelor vs. clopidogrel. MACE was defined as a composite of cardiovascular death, myocardial infarction, or stroke. Patients were followed for 12 months. Inverse probability of treatment weighting was used to adjust for 46 baseline confounders. We used weighted Cox proportional hazards regre

SUBMITTER: Marxer CA 

PROVIDER: S-EPMC12450599 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature