Single-cell multi-omics data reveal heterogeneity in liver tissue microenvironment induced by hypertension.

ABSTRACT: Hypertension (HTN) may induce liver damage; however, the effects on liver cell subpopulations remain obscure. Understanding these microenvironmental changes could offer early HTN and liver disease indicators. We employed single-cell multi-omics and histone chromatin immunoprecipitation sequencing (ChIP-seq) to scrutinize microenvironmental alterations between normal and HTN liver tissues. Our analysis revealed an HTN-related hepatocyte subpopulation, termed "Hepatocytes_1," via single-cell RNA sequencing (scRNA-seq). Five potential pathogenic genes (UPB1, SDS, PCCA, CYP3A4, and PPARGC1A) were identified in Hepatocytes_1. Additionally, the regulatory network of cis-regulatory elements (CREs) in genes within Hepatocytes_1 was unveiled using single-cell assay for transposase accessible

SUBMITTER: Li H 

PROVIDER: S-EPMC12450633 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature