Nup93-Mediated RNA Alternative Splicing Associated With Diabetic Atherosclerosis.

ABSTRACT: Atherosclerosis, a life-threatening complication of diabetes mellitus (DM), significantly increases the mortality risk among diabetic patients. Vascular smooth muscle cells (VSMCs) not only constitute the core of atherosclerotic lesions but also serve as primary components of plaques. Although diabetes expedites this transformation process, the specific mechanism remains elusive. Traditional proteomic approaches that analyze average signals of all cells overlook the importance of spatial information, although different cells within the same tissue exhibit distinct molecular characteristics during various stages of atherosclerosis progression. In this study, we employed spatial proteomic technology to comprehensively analyze proteins in vascular smooth muscle tissues and atherosclerotic pla

SUBMITTER: Yuan X 

PROVIDER: S-EPMC12450644 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature