Sex-specific association between body mass index and cerebral microbleed progression in adults aged 50-85 years.

ABSTRACT:

Background and purpose

Previous studies have demonstrated sex differences in the association between body mass index (BMI) and hemorrhagic stroke. Cerebral microbleed (CMB) is a clinically important marker of bleeding-prone microangiopathy, which is associated with a risk of hemorrhagic stroke. No study has evaluated sex differences in the relationship between BMI and CMB. In this longitudinal study, we aimed to conduct sex-stratified analyses to assess whether sex modifies the effect of BMI on CMB progression.

Methods

The database of the CHALLENGE study (Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes), which enrolled patients aged 50-85 years with cerebral small vessel disease, was analyzed. Of the 256 s

SUBMITTER: Yoon CW 

PROVIDER: S-EPMC12450651 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature