Prognostic model of ubiquitination-related genes in ovarian cancer based on transcriptomic analysis and experimental validation.

ABSTRACT:

Objective

Ubiquitination plays a crucial role in the malignant progression of ovarian cancer. With the advent of proteolysis-targeting chimeras (PROTACs) targeting ubiquitin enzymes, precision therapies are now possible. Therefore, it is imperative to ascertain the prognostic significance of ubiquitination-related genes in ovarian cancer.

Methods

A prognostic model based on ubiquitination-related genes was developed using data from TCGA and GTEx databases. Performance was assessed via Kaplan-Meier, ROC curves, and Cox regression; a nomogram was created. The model's stability was checked using training and test sets. FBXO45 was also experimentally validated in ovarian cancer.

Results

The model, based on 17 genes related to ubiquitination, showed high performance (1-yea

SUBMITTER: Lin X 

PROVIDER: S-EPMC12450667 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature